Main Characters:
- Vladimir "Vlad" Dracula - Gerran Howell (series 1-5)
- Ingrid Dracula - Clare Thomas (series 1-5)
- Count Dracula - Keith-Lee Castle (series 1-5)
- Renfield - Simon Ludders (series 1-5)
- Zoltan - Andy Bradshaw (voice) (series 1-3)
- Robin Branaugh - Craig Roberts (series 1-2)
- Erin Noble - Sydney Rae White (series 3-4)
- Bertrand de Fortunesa - Cesare Taurasi (series 3-4)
- Alex McCauley - Letty Butler (series 3-4)
- Wolfie - Lorenzo Rodriguez (series 3-4)
- Malik - Richard Southgate (series 4-5)
Recurring Characters:
- Magda Westenra - Donna Grant (series 1-3)
- Chloe Branaugh - Lucy Borja (series 1-2)
- Ian Branaugh - Ben McGregor (series 1-2)
- Paul Branaugh - Luke Bridgeman (series 1-2)
- Graham Branaugh - Aneirin Hughes (series 1-2)
- Elizabeth Branaugh - Beth Robert (series 1-2)
- Eric Van Helsing - Terence Maynard (series 1-2)
- Jonathan Van Helsing - Terry Haywood (series 1-4)
- Mina Van Helsing - Jo-Anne Knowles (series 2-4)
- Ivan Dracula - Phillip Brodie (series 2)
- Boris Dracula - Ciaran Joyce (series 2)
- Olga Dracula - Maddie Rakic-Platt (series 2)
- Will Clarke - Harry Ferrier (series 2)
- Ryan Noble - Tom Gibbons (series 3-4)
- Ramanga - Robbie Gee (series 3-4)
- Asan Ramanga - Quinton Nyirenda (series 5)
- Sally Giles - Laura Howard (series 5)
- George Giles - Bella Band (series 5)
- Talitha - Eleanor Gecks (series 5)